Leitner Group
Cross-linking-based structural proteomics
Our group uses different cross-linking methods in combination with mass spectrometric analysis to learn about the structural organization of protein and protein-RNA complexes. Cross-linking can provide important spatial information that can be combined with other experimental and computational methods in integrative structural biology.
More details here
Scroll down for group news!
Contact
Inst. f. Molekulare Systembiologie
Otto-Stern-Weg 3
8093
Zürich
Switzerland
Group news
Welcome Dinko
01.09.2025
The Leitner group welcomes Dinko Soic! He has been selected as an ETH Postdoctoral Fellow and will contribute his expertise in glycoproteomics.
New publications
11.08.2025
external page Our publication in Nucleic Acids Research highlights an improved protocol for protein-RNA cross-linking using our CLIR-MS approach and shows how protein-RNA cross-links can be used as distance restraints in structural modeling. The project was led by former PhD student, Chris Sarnowski.
Former postdoctoral researcher Esben Trabjerg recently published a study combining cross-linking and hydrogen/deuterium exchange coupled to MS to study the interaction between IgG-type antibodies and the neonatal Fc receptor (FcRn). Check out his work in external page Communications Biology.