Publications

Here are our most recent publications, starting from 2016. For a complete list, see external pageScopus or external pageORCID.

(Corresponding authors are underlined, * means equal contribution)

Jung T.*, Shin B.*, Tamo G.*, Kim H.*, Vijayvargia R.*, Leitner A., Marcaida M. J., Astorga-Wells J., Jung R., Aebersold R., Del Peraro M., Hebert H., Seong I. S., Song, J.-J. The Polyglutamine Expansion at the N-Terminal of Huntingtin Protein Modulates the Dynamic Configuration and Phosphorylation of the C-Terminal HEAT Domain. Structure 28 (2020) 1035-1050. external pageLink to paper external pageLink to data on PRIDE
Poghosyan E., Iacovache I., Faltova L., Leitner A., Yang P., Diener D. R., Aebersold R., Zuber B., Ishikawa T. The structure and symmetry of radial spoke protein complex in Chlamydomonas flagella. J. Cell Sci. 133 (2020) jcs245233. external pageLink to paper external pageLink to data on PRIDE
Arora Verasztó H., Logotheti M., Albrecht R., Leitner A., Zhu H., Hartmann M. D. Architecture and functional dynamics of the pentafunctional AROM complex. Nat. Chem. Biol. 16 (2020) 973-978. external pageLink to paper external pageLink to data on PRIDE
Sabath K., Stäubli M. L., Marti S., Leitner A., Moes M., Jonas S. INTS10–INTS13–INTS14 form a functional module of Integrator that binds nucleic acids and the cleavage module, Nat. Commun. 11 (2020) 3422. Open Access external pageLink to paper external pageLink to data on PRIDE(1) external pageLink to data on PRIDE(2)
Klatt F., Leitner A., Kim I. V., Ho-Xuan H., Schneider E. V., Langhammer F., Weinmann R., Müller M. R., Huber R., Meister G., Kuhn C.-D. A precisely positioned MED12 activation helix stimulates CDK8 kinase activity, Proc. Natl. Acad. Sci. USA 117 (2020) 2894-2905. external pageLink to paper external pageLink to data on PRIDE
Berman H. M., Adams P. ., Bonvin A. A., Burley S. K., Carragher B., Chiu W., DiMaio F., Ferrin T. E., Gabanyi M. J., Goddard T. D., Griffin P. R., Haas J., Hanke C. A., Hoch J. C., Hummer G., Kurisu G., Lawson C. L., Leitner A., Markley J. L., Meiler J., Montelione G. T., Philips Jr. G. N., Prisner T., Rappsilber J., Schriemer D. C., Schwede T., Seidel C. A. M., Strutzenberg T. S., Svergun D. I., Tajkhorshid E., Trewhella J., Vallat B., Velankar S., Vuister G. W., Webb B., Westbrook J. D., White K. L., Sali A., Federating Structural Models and Data: Outcomes from A Workshop on Archiving Integrative Structures, Structure 27 (2019) 1745-1759. external pageLink to paper
Fajardo J. E., Shrestha R., Gil N., Belsom A., Crivelli S. N., Czaplewski C., Fidelis K., Grudinin S., Karasikov M., Karczyńska A. S., Kryshtafovych A., Leitner A., Liwo A., Lubecka E. A., Monastyrskyy B., Pagès G., Rappsilber J., Sieradzan A. K., Sikorska C., Trabjerg E., Fiser A., Assessment of chemical‐crosslink‐assisted protein structure modeling in CASP13, Proteins 87 (2019) 1283-1297. Open Access external pageLink to paper
Saurer M.*, Ramrath D. J. F.*, Niemann M.*, Calderaro S., Prange C., Mattei S., Scailola A., Leitner A., Bieri P., Horn E. K., Leibundgut M., Boehringer D., Schneider A., Ban N., Mitoribosomal small subunit biogenesis in trypanosomes involves an extensive assembly machinery, Science 365 (2019) 1144-1149. external pageLink to paper external pageLink to data on PRIDE
Wongpalee S. P., Liu S., Gallego-Bartolomé J., Leitner A., Aebersold R., Liu W., Yen L., Nohales M. A., Kuo P. H., Vashisht A. A., Wohlschlegel J. A., Feng S., Kay S. A., Zhou Z. H., Jacobsen S. E., CryoEM Structures of Arabidopsis DDR Complexes Involved in RNA-directed DNA Methylation, Nat. Commun. 10 (2019) 3916. Open Access external pageLink to paper external pageLink to data on PRIDE
Paulitschke V., Eichhoff O., Gerner C., Paulitschke P., Bileck A., Mohr T., Cheng P. F., Leitner A., Guenova E., Saulite I., Freiberger S. N., Irmisch A., Knapp B., Zila N., Chatziisaak T.-P., Stephan J., Mangana J., Kunstfeld R., Pehamberger H., Aebersold R., Dummer R., Levesque M. P., Proteomic identification of a marker signature for MAPKi resistance in melanoma, EMBO J. 38 (2019) e95874. external pageLink to paper
Leitner A., Dorn G., Allain F. H.-T., Combining Mass Spectrometry (MS) and Nucleic Magnetic Resonance (NMR) Spectroscopy for Integrative Structural Biology of Protein-RNA Complexes, Cold Spring Harbor Perspectives in Biology 11 (2019) a032359. external pageLink to paper
Iacobucci C., Piotrowski C., …, Leitner A., Sinz A., The First Community-Wide, Comparative Cross-linking Mass Spectrometry Study, Anal. Chem. 91 (2019) 6953-6961. Open Access external pageLink to paper
Gestaut D.*, Roh S. H.*, Ma B.*, Pintilie G., Joachimiak L. A., Leitner A., Walzthoeni T., Aebersold R., Chiu W., Frydman J., The Chaperonin TRiC/CCT Associates with Prefoldin through a Conserved Electrostatic Interface Essential for Cellular Proteostasis, Cell 177 (2019) 751-765. external pageLink to paper
Ramrath D. J. F.*, Niemann M.*, Leibundgut M., Bieri P., Prange C., Horn E. K., Leitner A., Boehringer D., Schneider A., Ban N., Evolutionary shift towards protein-based architecture in trypanosomal mitochondrial ribosomes, Science 362 (2018) eaau7735. external pageLink to paper
Chowdhury S.*, Otomo C.*, Leitner A., Ohashi K., Aebersold R., Lander G. C., Otomo T., Insights into autophagosome biogenesis from structural and biochemical analyses of the ATG2A-WIPI4 complex, Proc. Natl. Acad. Sci. USA 115 (2018) E9792-E9801. Open Access external pageLink to paper
Schütz S.*, Michel E.*, Damberger F. F., Oplová M., Peña C., Leitner A., Aebersold R., Allain F. H.-T., Panse V. G., Molecular basis for disassembly of an importin:ribosomal protein complex by the escortin Tsr2, Nat. Commun. 9 (2018) 3669. Open Access external pageLink to paper external pageLink to data on PRIDE
Martinez-Martin N., Marcandalli J., Huang C. S., Arthur C. P., Perotti M., Foglierini M., Ho H., Dosey A. M., Shriver S., Payandeh J., Leitner A., Lanzavecchia A., Perez L., Ciferri C., An Unbiased Screen for Human Cytomegalovirus Identifies Neuropilin-2 as a Central Viral Receptor, Cell 174 (2018) 1158-1171. external pageLink to paper external pageLink to data on PRIDE
Bleichert F., Leitner A., Aebersold R., Botchan M. R., Berger J. M., Conformational control and DNA binding mechanism of the metazoan origin recognition complex, Proc. Natl. Acad. Sci. USA 115 (2018) E5906-E5915. Open Access external pageLink to paper external pageLink to data on PRIDE
Yoon J., Kim S. J., An S., Cho S., Leitner A., Jung T., Aebersold R., Hebert H., Cho U.-S., Song J.-J., Integrative Structural Investigation on the Architecture of Human Importin4_Histone H3/H4_Asf1a Complex and its Histone H3 Tail Binding, J. Mol. Biol. 430 (2018) 822-841. external pageLink to paper
Eliseev B., Yeramala L., Leitner A., Karuppasamy M., Raimondeau E., Huard K., Alkalaeva E., Aebersold R., Schaffitzel C., Structure of a human cap-dependent 48S translation pre-initiation complex, Nucl. Acids Res. 46 (2018) 2678-2689. Open Access external pageLink to paper
Leitner A., A review of the role of chemical modification methods in contemporary mass spectrometry-based proteomics research, Anal. Chim. Acta. 1000 (2018) 2-19. external pageLink to paper
Lehmann L. C.*, Hewitt G.*, Aibara S., Leitner A., Marklund E., Maslen S. L., Maturi V., Chen Y., van der Spoel D., Skehel J. M., Moustakas A., Boulton S. J., Deindl S., Mechanistic Insights into Autoinhibition of the Oncogenic Chromatin Remodeler ALC1, Mol. Cell 68 (2017) 847-859. Open Access external pageLink to paper
Vizcaíno J. A., Mayer G., Perkins S., Barsnes H., Vaudel M., Perez-Riverol Y., Ternent T., Uszkoreit J., Eisenacher M., Fischer L., Rappsilber J., Netz E., Walzer M., Kohlbacher O., Leitner A., Chalkley R. J., Ghali F., Martínez-Bartolomé S., Deutsch E. W., Jones A. R., The mzIdentML data standard version 1.2, supporting advances in proteome informatics, Mol. Cell. Proteomics 16 (2017) 1275-1285. Open Access external pageLink to paper
Leitner A., Sakeye M., Zimmerli C. E., Smått J.-H., A Systematic Evaluation of Nanocast Metal Oxide Microspheres Providing New Insights for Applications in Phosphoproteomics, Analyst 142 (2017) 1993-2003. external pageLink to paper external pageLink to data on PRIDE
Dorn G.*, Leitner A.*, Boudet J., Campagne S., von Schroetter C., Moursy A., Aebersold R., Allain F. H.-T., Structural modeling of protein-RNA complexes using crosslinking of segmentally isotope labeled RNA and MS/MS, Nat. Methods 14 (2017) 487-490. external pageLink to paper external pageLink to protocol on Protocol Exchange external pageLink to data on PRIDE
Wang X., Cimermancic P., Yu C., Schweitzer A., Chopra N., Engel J. L., Greenberg C. H., Huszagh A. S., Beck F., Sakata E., Yang Y., Novitsky E. J., Leitner A., Nanni P., Kahraman A., Guo X., Dixon J. E., Rychnovsky S. D., Aebersold R., Baumeister W., Sali A., and Huang L., Molecular Details Underlying Dynamic Structures and Regulation of the Human 26S Proteasome, Mol. Cell. Proteomics 16 (2017) 840-854. external pageLink to paper
Ciuffa R., Caron E., Leitner A., Uliana F., Gstaiger M., Aebersold R., Contribution of Mass Spectrometry-Based Proteomics to the Understanding of TNF-α Signaling, J. Proteome Res. 16 (2017) 14-33. external pageLink to paper
Leitner A., Application of chemical cross-linking/mass spectrometry to probe protein structures, Encyclopedia of Analytical Chemistry (2016), article a9549. external pageLink to paper
Leitner A., Cross-linking and other structural proteomics techniques: how chemistry is enabling mass spectrometry applications in structural biology, Chem. Sci. 7 (2016) 4792-4803. Open Access external pageLink to paper
Gillet L. C.*, Leitner A.*, Aebersold R., Mass Spectrometry Applied to Bottom-Up Proteomics: Entering the High-Throughput Era for Hypothesis Testing, Annu. Rev. Anal. Chem. 9 (2016) 449-472. external pageLink to paper
Kim D.*, Setiaputra D.*, Jung T.*, Chung J., Leitner A., Yoon J., Aebersold R., Hebert H., Yip C. K., Song J.-J., Molecular Architecture of Yeast Chromatin Assembly Factor 1, Sci. Rep. 6 (2016) 26702. Open Access external pageLink to paper
Mosadeghi R.*, Reichermeier K. M., Winkler M., Schreiber A., Reitsma J., Stengel F., Cao J., Kim M., Sweredoski M., Hess S., Leitner A., Aebersold R., Peter M., Deshaies R. J., Enchev R. I.*, Structural and kinetic analysis of the COP9-Signalosome activation and the cullin–RING ubiquitin ligase deneddylation cycle, eLife 5 (2016) e12102. Open Access external pageLink to paper
Vijayvargia R., Epand R., Leitner A., Jung T.-Y., Shin B., Jung R., Lloret A., Atwal R. S., Lee H., Lee J.-M., Aebersold R., Hebert H., Song J.-J., Seong I. S., Huntingtin’s spherical solenoid structure enables polyglutamine tract-dependent modulation of its structure and function, eLife 5 (2016) e11184. Open Access external pageLink to paper
Greber B. J., Gerhardy S., Leitner A., Leibundgut M., Salem M., Boehringer D., Leulliot N., Aebersold R., Panse V., Ban N., Insertion of the Biogenesis Factor Rei1 Probes the Ribosomal Tunnel during 60S Maturation, Cell 164 (2016) 91-102. Open Access external pageLink to paper
Leitner A., Faini M., Stengel F., Aebersold R., Cross-linking and mass spectrometry: An integrated technology to understand structure and function of molecular machines, Trends Biochem. Sci. 41 (2016) 20-32. external pageLink to paper
Leitner A., Enrichment Strategies in Phosphoproteomics (book chapter), Meth. Mol. Biol. - Phospho-Proteomics, 2nd edition, 1355 (2016) 105-121. external pageLink to paper