Institute of Molecular Systems Biology

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Publications

Here are our most recent publications, starting from 2016. For a complete list, see external page Scopus or external page ORCID.

(Corresponding authors are underlined, * means equal contribution)

  • Jung T.*, Shin B.*, Tamo G.*, Kim H.*, Vijayvargia R.*, Leitner A., Marcaida M. J., Astorga-Wells J., Jung R., Aebersold R., Del Peraro M., Hebert H., Seong I. S., Song, J.-J. The Polyglutamine Expansion at the N-Terminal of Huntingtin Protein Modulates the Dynamic Configuration and Phosphorylation of the C-Terminal HEAT Domain. Structure 28 (2020) 1035-1050. external page Link to paper external page Link to data on PRIDE
  • Poghosyan E., Iacovache I., Faltova L., Leitner A., Yang P., Diener D. R., Aebersold R., Zuber B., Ishikawa T. The structure and symmetry of radial spoke protein complex in Chlamydomonas flagella. J. Cell Sci. 133 (2020) jcs245233. external page Link to paper external page Link to data on PRIDE
  • Arora Verasztó H., Logotheti M., Albrecht R., Leitner A., Zhu H., Hartmann M. D. Architecture and functional dynamics of the pentafunctional AROM complex. Nat. Chem. Biol. 16 (2020) 973-978. external page Link to paper external page Link to data on PRIDE
  • Sabath K., Stäubli M. L., Marti S., Leitner A., Moes M., Jonas S. INTS10–INTS13–INTS14 form a functional module of Integrator that binds nucleic acids and the cleavage module, Nat. Commun. 11 (2020) 3422. Open Access external page Link to paper external page Link to data on PRIDE(1) external page Link to data on PRIDE(2)
  • Klatt F., Leitner A., Kim I. V., Ho-Xuan H., Schneider E. V., Langhammer F., Weinmann R., Müller M. R., Huber R., Meister G., Kuhn C.-D. A precisely positioned MED12 activation helix stimulates CDK8 kinase activity, Proc. Natl. Acad. Sci. USA 117 (2020) 2894-2905. external page Link to paper external page Link to data on PRIDE
  • Berman H. M., Adams P. ., Bonvin A. A., Burley S. K., Carragher B., Chiu W., DiMaio F., Ferrin T. E., Gabanyi M. J., Goddard T. D., Griffin P. R., Haas J., Hanke C. A., Hoch J. C., Hummer G., Kurisu G., Lawson C. L., Leitner A., Markley J. L., Meiler J., Montelione G. T., Philips Jr. G. N., Prisner T., Rappsilber J., Schriemer D. C., Schwede T., Seidel C. A. M., Strutzenberg T. S., Svergun D. I., Tajkhorshid E., Trewhella J., Vallat B., Velankar S., Vuister G. W., Webb B., Westbrook J. D., White K. L., Sali A., Federating Structural Models and Data: Outcomes from A Workshop on Archiving Integrative Structures, Structure 27 (2019) 1745-1759. external page Link to paper
  • Fajardo J. E., Shrestha R., Gil N., Belsom A., Crivelli S. N., Czaplewski C., Fidelis K., Grudinin S., Karasikov M., Karczyńska A. S., Kryshtafovych A., Leitner A., Liwo A., Lubecka E. A., Monastyrskyy B., Pagès G., Rappsilber J., Sieradzan A. K., Sikorska C., Trabjerg E., Fiser A., Assessment of chemical‐crosslink‐assisted protein structure modeling in CASP13, Proteins 87 (2019) 1283-1297. Open Access external page Link to paper
  • Saurer M.*, Ramrath D. J. F.*, Niemann M.*, Calderaro S., Prange C., Mattei S., Scailola A., Leitner A., Bieri P., Horn E. K., Leibundgut M., Boehringer D., Schneider A., Ban N., Mitoribosomal small subunit biogenesis in trypanosomes involves an extensive assembly machinery, Science 365 (2019) 1144-1149. external page Link to paper external page Link to data on PRIDE
  • Wongpalee S. P., Liu S., Gallego-Bartolomé J., Leitner A., Aebersold R., Liu W., Yen L., Nohales M. A., Kuo P. H., Vashisht A. A., Wohlschlegel J. A., Feng S., Kay S. A., Zhou Z. H., Jacobsen S. E., CryoEM Structures of Arabidopsis DDR Complexes Involved in RNA-directed DNA Methylation, Nat. Commun. 10 (2019) 3916. Open Access external page Link to paper external page Link to data on PRIDE
  • Paulitschke V., Eichhoff O., Gerner C., Paulitschke P., Bileck A., Mohr T., Cheng P. F., Leitner A., Guenova E., Saulite I., Freiberger S. N., Irmisch A., Knapp B., Zila N., Chatziisaak T.-P., Stephan J., Mangana J., Kunstfeld R., Pehamberger H., Aebersold R., Dummer R., Levesque M. P., Proteomic identification of a marker signature for MAPKi resistance in melanoma, EMBO J. 38 (2019) e95874. external page Link to paper
  • Leitner A., Dorn G., Allain F. H.-T., Combining Mass Spectrometry (MS) and Nucleic Magnetic Resonance (NMR) Spectroscopy for Integrative Structural Biology of Protein-RNA Complexes, Cold Spring Harbor Perspectives in Biology 11 (2019) a032359. external page Link to paper
  • Iacobucci C., Piotrowski C., …, Leitner A., Sinz A., The First Community-Wide, Comparative Cross-linking Mass Spectrometry Study, Anal. Chem. 91 (2019) 6953-6961. Open Access external page Link to paper
  • Gestaut D.*, Roh S. H.*, Ma B.*, Pintilie G., Joachimiak L. A., Leitner A., Walzthoeni T., Aebersold R., Chiu W., Frydman J., The Chaperonin TRiC/CCT Associates with Prefoldin through a Conserved Electrostatic Interface Essential for Cellular Proteostasis, Cell 177 (2019) 751-765. external page Link to paper
  • Ramrath D. J. F.*, Niemann M.*, Leibundgut M., Bieri P., Prange C., Horn E. K., Leitner A., Boehringer D., Schneider A., Ban N., Evolutionary shift towards protein-based architecture in trypanosomal mitochondrial ribosomes, Science 362 (2018) eaau7735. external page Link to paper
  • Chowdhury S.*, Otomo C.*, Leitner A., Ohashi K., Aebersold R., Lander G. C., Otomo T., Insights into autophagosome biogenesis from structural and biochemical analyses of the ATG2A-WIPI4 complex, Proc. Natl. Acad. Sci. USA 115 (2018) E9792-E9801. Open Access external page Link to paper
  • Schütz S.*, Michel E.*, Damberger F. F., Oplová M., Peña C., Leitner A., Aebersold R., Allain F. H.-T., Panse V. G., Molecular basis for disassembly of an importin:ribosomal protein complex by the escortin Tsr2, Nat. Commun. 9 (2018) 3669. Open Access external page Link to paper external page Link to data on PRIDE
  • Martinez-Martin N., Marcandalli J., Huang C. S., Arthur C. P., Perotti M., Foglierini M., Ho H., Dosey A. M., Shriver S., Payandeh J., Leitner A., Lanzavecchia A., Perez L., Ciferri C., An Unbiased Screen for Human Cytomegalovirus Identifies Neuropilin-2 as a Central Viral Receptor, Cell 174 (2018) 1158-1171. external page Link to paper external page Link to data on PRIDE
  • Bleichert F., Leitner A., Aebersold R., Botchan M. R., Berger J. M., Conformational control and DNA binding mechanism of the metazoan origin recognition complex, Proc. Natl. Acad. Sci. USA 115 (2018) E5906-E5915. Open Access external page Link to paper external page Link to data on PRIDE
  • Yoon J., Kim S. J., An S., Cho S., Leitner A., Jung T., Aebersold R., Hebert H., Cho U.-S., Song J.-J., Integrative Structural Investigation on the Architecture of Human Importin4_Histone H3/H4_Asf1a Complex and its Histone H3 Tail Binding, J. Mol. Biol. 430 (2018) 822-841. external page Link to paper
  • Eliseev B., Yeramala L., Leitner A., Karuppasamy M., Raimondeau E., Huard K., Alkalaeva E., Aebersold R., Schaffitzel C., Structure of a human cap-dependent 48S translation pre-initiation complex, Nucl. Acids Res. 46 (2018) 2678-2689. Open Access external page Link to paper
  • Leitner A., A review of the role of chemical modification methods in contemporary mass spectrometry-based proteomics research, Anal. Chim. Acta. 1000 (2018) 2-19. external page Link to paper 
  • Lehmann L. C.*, Hewitt G.*, Aibara S., Leitner A., Marklund E., Maslen S. L., Maturi V., Chen Y., van der Spoel D., Skehel J. M., Moustakas A., Boulton S. J., Deindl S., Mechanistic Insights into Autoinhibition of the Oncogenic Chromatin Remodeler ALC1, Mol. Cell 68 (2017) 847-859. Open Access external page Link to paper
  • Vizcaíno J. A., Mayer G., Perkins S., Barsnes H., Vaudel M., Perez-Riverol Y., Ternent T., Uszkoreit J., Eisenacher M., Fischer L., Rappsilber J., Netz E., Walzer M., Kohlbacher O., Leitner A., Chalkley R. J., Ghali F., Martínez-Bartolomé S., Deutsch E. W., Jones A. R., The mzIdentML data standard version 1.2, supporting advances in proteome informatics, Mol. Cell. Proteomics 16 (2017) 1275-1285. Open Access external page Link to paper 
  • Leitner A., Sakeye M., Zimmerli C. E., Smått J.-H., A Systematic Evaluation of Nanocast Metal Oxide Microspheres Providing New Insights for Applications in Phosphoproteomics, Analyst 142 (2017) 1993-2003. external page Link to paper external page Link to data on PRIDE
  • Dorn G.*, Leitner A.*, Boudet J., Campagne S., von Schroetter C., Moursy A., Aebersold R., Allain F. H.-T., Structural modeling of protein-RNA complexes using crosslinking of segmentally isotope labeled RNA and MS/MS, Nat. Methods 14 (2017) 487-490. external page Link to paper external page Link to protocol on Protocol Exchange external page Link to data on PRIDE
  • Wang X., Cimermancic P., Yu C., Schweitzer A., Chopra N., Engel J. L., Greenberg C. H., Huszagh A. S., Beck F., Sakata E., Yang Y., Novitsky E. J., Leitner A., Nanni P., Kahraman A., Guo X., Dixon J. E., Rychnovsky S. D., Aebersold R., Baumeister W., Sali A., and Huang L., Molecular Details Underlying Dynamic Structures and Regulation of the Human 26S Proteasome, Mol. Cell. Proteomics 16 (2017) 840-854. external page Link to paper
  • Ciuffa R., Caron E., Leitner A., Uliana F., Gstaiger M., Aebersold R., Contribution of Mass Spectrometry-Based Proteomics to the Understanding of TNF-α Signaling, J. Proteome Res. 16 (2017) 14-33. external page Link to paper
  • Leitner A., Application of chemical cross-linking/mass spectrometry to probe protein structures, Encyclopedia of Analytical Chemistry (2016), article a9549. external page Link to paper
  • Leitner A., Cross-linking and other structural proteomics techniques: how chemistry is enabling mass spectrometry applications in structural biology, Chem. Sci. 7 (2016) 4792-4803. Open Access external page Link to paper
  • Gillet L. C.*, Leitner A.*, Aebersold R., Mass Spectrometry Applied to Bottom-Up Proteomics: Entering the High-Throughput Era for Hypothesis Testing, Annu. Rev. Anal. Chem. 9 (2016) 449-472. external page Link to paper
  • Kim D.*, Setiaputra D.*, Jung T.*, Chung J., Leitner A., Yoon J., Aebersold R., Hebert H., Yip C. K., Song J.-J., Molecular Architecture of Yeast Chromatin Assembly Factor 1, Sci. Rep. 6 (2016) 26702. Open Access external page Link to paper
  • Mosadeghi R.*, Reichermeier K. M., Winkler M., Schreiber A., Reitsma J., Stengel F., Cao J., Kim M., Sweredoski M., Hess S., Leitner A., Aebersold R., Peter M., Deshaies R. J., Enchev R. I.*, Structural and kinetic analysis of the COP9-Signalosome activation and the cullin–RING ubiquitin ligase deneddylation cycle, eLife 5 (2016) e12102. Open Access external page Link to paper
  • Vijayvargia R., Epand R., Leitner A., Jung T.-Y., Shin B., Jung R., Lloret A., Atwal R. S., Lee H., Lee J.-M., Aebersold R., Hebert H., Song J.-J., Seong I. S., Huntingtin’s spherical solenoid structure enables polyglutamine tract-dependent modulation of its structure and function, eLife 5 (2016) e11184. Open Access external page Link to paper
  • Greber B. J., Gerhardy S., Leitner A., Leibundgut M., Salem M., Boehringer D., Leulliot N., Aebersold R., Panse V., Ban N., Insertion of the Biogenesis Factor Rei1 Probes the Ribosomal Tunnel during 60S Maturation, Cell 164 (2016) 91-102. Open Access external page Link to paper
  • Leitner A., Faini M., Stengel F., Aebersold R., Cross-linking and mass spectrometry: An integrated technology to understand structure and function of molecular machines, Trends Biochem. Sci. 41 (2016) 20-32. external page Link to paper
  • Leitner A., Enrichment Strategies in Phosphoproteomics (book chapter), Meth. Mol. Biol. - Phospho-Proteomics, 2nd edition, 1355 (2016) 105-121. external page Link to paper
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