Juan Atilio Gerez
Juan completed his undergraduate studies in biology at Buenos Aires University, Argentina. He did his PhD at the same university (2005-2010) and in his thesis, Juan characterized a recently identified protein involved in the SUMOylation and hypoxia signaling pathways. Juan came to the Picotti lab to learn how to apply systems biology concepts, such as discovery and targeted proteomics, to characterize cellular responses to protein misfolding, either in physiological or pathological contexts. He used dopaminergic neuronal cells as a model system for protein aggregation-dependent cytotoxicity characteristics of several human neurodegenerative diseases like Alzheimer’s and Parkinson’s Disease. Juan was a postdoctoral fellow of the European Molecular Biology Organization (EMBO).
Publications
M.A. Krzyzaniak, M.T. Zumstein, J.A. Gerez, P. Picotti, A. Helenius. external page Host cell entry of respiratory syncytial virus involves macropinocytosis followed by proteolytic activation of the f protein. (2013) PLoS Pathog., Apr (4):e1003309.
J. Druker, A.C. Liberman, M. Antunica-Noguerol, J. Gerez, M. Paez-Pereda, T. Rein, J.A. Iñiguez-Lluhí, F. Holsboer, E. Arzt. external page RSUME enhances Glucocorticoid Receptor SUMOylation and transcriptional activity. (2013) Mol Cell Biol., 33(11):2116-27
J. Gerez, M. Fuertes, L. Tedesco, S. Silberstein, G. Sevlever, M. Paez-Pereda, F. Holsboer, A.G. Turjanski, E. Arzt. external page In Silico Structural and Functional Characterization of the RSUME Splice Variants. (2013) PLoS One, 2013;8(2).
B. Shan, J. Gerez, M. Haedo, M. Fuertes, M. Theodoropoulou, M. Buchfelder, M. Losa, G.K. Stalla, E. Arzt, U. Renner. external page RSUME is implicated in HIF-1-induced VEGF-A production in pituitary tumour cells. (2012) Endocr Relat Cancer, 19(1):13-27
F. Pelisch, J. Gerez, J. Druker, I.E. Schor, M.J. Muñoz, G. Risso, E. Petrillo, B.J. Westman, A.I. Lamond, E. Arzt, A. Srebrow. external page The serine/arginine-rich protein SF2/ASF regulates protein sumoylation. (2010) Proc Natl Acad Sci. U S A, 107(37):16119-24.
M. Fuertes, J. Gerez, M. Haedo, D. Giacomini, M. Páez-Pereda, M. Labeur, G.K. Stalla, E. Arzt. external page Cytokines and genes in pituitary tumorigenesis: RSUME role in cell biology. (2010) Front Horm Res., 38:1-6.
D. Giacomini, M. Haedo, J. Gerez, J. Druker, M. Páez-Pereda, M. Labeur, G.K. Stalla, E. Arzt. external page Differential gene expression in models of pituitary prolactin-producing tumoral cells. (2009) Horm Res., 71 Suppl 2:88-94.
U. Renner, E.C. De Santana, J. Gerez, B. Fröhlich, M. Haedo, M.P. Pereda, C. Onofri, G.K. Stalla, E. Arzt. external page Intrapituitary expression and regulation of the gp130 cytokine interleukin-6 and its implication in pituitary physiology and pathophysiology. (2009) Ann N Y Acad Sci.,1153:89-97.
M.R. Haedo, J. Gerez, M. Fuertes, D. Giacomini, M. Páez-Pereda, M. Labeur, U. Renner, G.K. Stalla, E. Arzt. external page Regulation of pituitary function by cytokines. (2009) Horm Res., 72(5):266-74.
A. Carbia-Nagashima*, J. Gerez*, C. Perez-Castro, M. Paez-Pereda, S. Silberstein, G.K. Stalla, F. Holsboer, E. Arzt. external page RSUME, a small RWD-containing protein, enhances SUMO conjugation and stabilizes HIF-1alpha during hypoxia. (2007) Cell, 131(2):309-23. (*Equally contributed)
J. Gerez, J. Bonfiglio, S. Sosa, D. Giacomini, M. Acuña, A.C. Nagashima, M.J. Perone, S. Silberstein, U. Renner, G.K. Stalla, E. Arzt. external page Molecular transduction mechanisms of cytokine-hormone interactions: role of gp130 cytokines. (2007) Exp Physiol., 92(5):801-6.
D. Giacomini, M. Acuña, J. Gerez, A.C. Nagashima, S. Silberstein, M. Páez-Pereda, M. Labeur, M. Theodoropoulou, U. Renner, G.K. Stalla, E. Arzt. external page Pituitary action of cytokines: focus on BMP-4 and gp130 family. (2007) Neuroendocrinology. 85(2):94-100.
D. Giacomini, M. Páez-Pereda, M. Theodoropoulou, J. Gerez, A.C. Nagashima, A. Chervin, S. Berner, M. Labeur, D. Refojo, U. Renner, G.K. Stalla, E. Arzt. external page Bone morphogenetic protein-4 control of pituitary pathophysiology. (2006) Front Horm Res., 35:22-31.
D. Giacomini, M. Páez-Pereda, M. Theodoropoulou, M. Labeur, D. Refojo, J. Gerez, A. Chervin, S. Berner, M. Losa, M. Buchfelder, U. Renner, G.K. Stalla, E. Arzt. external page Bone morphogenetic protein-4 inhibits corticotroph tumor cells: involvement in the retinoic acid inhibitory action. (2006) Endocrinology, 147(1):247-56.