Picotti Group

Research focus

Our laboratory is interested in how protein conformational changes, such as those associated with protein aggregation or allostery, impact cellular physiology and result in human disease. We develop mass spectrometry-based structural and chemical proteomic methods aimed at monitoring protein conformational changes in the complex cellular milieu. We combine these tools with classical biochemical, cell biological, and genetic approaches in several lines of research, listed below.

Research topics:

• Molecular bases of protein aggregation diseases
• Allostery and protein-metabolite interactions
• Determinants of proteome thermostability
• Structural systems biology