Martin Soste
Martin completed his BSc at the University of Victoria, Canada majoring in molecular biology. After his studies, he worked in the lab of Prof. Terry Pearson selecting antibodies for the enrichment of candidate biomarkers upstream of quantitative mass spectrometry (MS). He then further pursued MS method development in the lab of Prof. Ruedi Aebersold at ETH Zürich, where he obtained his MSc with a focus on using selected reaction monitoring for measuring cancer-associated proteins in human plasma.
Martin joined the Picotti lab as a PhD student in order to understand how cells cope with α-Synuclein (α-Syn) aggregation and its associated cytotoxicity. He will characterize proteome-wide responses to α-Syn aggregation and show how these are reverted or potentiated by a set of known genetic modulators.
Publications
M.M. Brodersen, F. Lampert, C.A. Barnes, M. Soste, W. Piwko, M. Peter. external pageCRL4(WDR23)-Mediated SLBP Ubiquitylation Ensures Histone Supply during DNA Replication. Mol Cell. 2016 May 19;62(4):627-35.
G. Kanfer, T. Courthéoux, M. Peterka, S. Meier, M. Soste, A. Melnik, K. Reis, P. Aspenström, M. Peter, P. Picotti, B. Kornmann. external pageMitotic redistribution of the mitochondrial network by Miro and Cenp-F. (2015) Nat. Commun., 6: 8015.
M. Soste, R. Hrabakova, S. Wanka, A. Melnik, P. Boersema, A. Maiolica, T. Wernas, M. Tognetti, C. von Mering, P. Picotti. external pageA sentinel protein assay for simultaneously quantifying cellular processes. (2014) Nat. Methods,11(10):1045-8.
Y. Feng, G. De Franceschi, A. Kahraman, M. Soste, A. Melnik, P.J. Boersema, P.P. de Laureto, Y. Nikolaev, A.P. Oliveira, P. Picotti. external pageGlobal analysis of protein structural changes in complex proteomes. (2014) Nat. Biotechnol., 32(10):1036-44.
G. Caraveo, P.K. Auluck, L. Whitesell, C.Y. Chung, V. Baru, E.V. Mosharov, X. Yan, M. Ben-Johny, M. Soste, P. Picotti, H. Kim, K.A. Caldwell, G.A. Caldwell, D. Sulzer, D. Yue, S. Lindquist. external pageCalcineurin determines toxic versus beneficial responses to α-synuclein. (2014) Proc. Natl. Acad. Sci. U.S.A., Aug 26;111(34):E3544-52.
M. Soste, P. Picotti. external pageA Complete Mass-spectrometric Map of a Eukaryotic Proteome. (2013) Chimia (Aarau), Sep;67(9):684.
F. Di Girolamo, P.G. Righetti, M. Soste, Y. Feng, P. Picotti. external pageReproducibility of combinatorial peptide ligand libraries for proteome capture evaluated by selected reaction monitoring. (2013) J. Proteomics, 89:215-26.
R. Hüttenhain, M. Soste, N. Selevsek, H. Röst, A. Sethi, C. Carapito, T. Farrah, E. W. Deutsch, U. Kusebauch, R. L. Moritz, E. Niméus-Malmström, O. Rinner, R. Aebersold. external pageReproducible Quantification of Cancer-Associated Proteins in Body Fluids Using Targeted Proteomics. (2012) Sci. Transl. Med. 4, 142ra94.
M. Razavi, M.E. Pope, M.V. Soste, B.A. Eyford, A.M. Jackson, N.L. Anderson, T.W. Pearson. external pageMALDI Immunoscreening (MiSCREEN): A method for selection of anti-peptide monoclonal antibodies for use in immunoproteomics. (2011) J Immunol Methods. 364, 50–64.
M.E. Pope, M.V. Soste, B.A. Eyford, N.L. Anderson, T.W. Pearson. external pageAnti-peptide antibody screening: Selection of high affinity monoclonal reagents by a refined surface plasmon resonance technique. (2009) J. Immunol. Methods. 341, 86–96.