Thomas Hauser

Thomas received his PhD from the Ludwig Maximilian University of Munich for his studies on molecular chaperones in the group of Dr. Manajit Hayer-Hartl and Prof. Ulrich Hartl at the Max Planck Institute of Biochemistry. There, his research interest focused on protein-protein interactions, especially deciphering the role of chaperones in the assembly of protein complexes. He examined the mechanistic role of specific assembly chaperones for a key photosynthetic protein, combining diverse techniques including electron microscopy, X-ray crystallography, cross-linking coupled to mass spectrometry, native mass spectrometry and in vitro reconstitution experiments. By virtue of his major interest in protein structure-function analysis, he aims to develop a novel structural proteomics approach based on limited proteolysis, developed in the laboratory of Prof. Paola Picotti, to gain functional insights based on structural transitions in enzymes, to unravel mechanisms of metabolic regulation on a cellular level.