Analytical services
We currently offer the following analytical services:
- Metabolomics: Untargeted analysis of polar and moderately non-polar metabolites, including drugs, xenobiotics, etc.
- Lipidomics: Untargeted analysis of all major lipid classes (> 1000 lipid species detected in serum)
All of our services rely on high-throughput mass spectrometry methods that scale to thousands of samples without compromising quality and turnaround.
The readouts are semi-quantitative, i.e. provide relative changes of each detectable compound across the study. On demand and for limited compounds, approximative amounts (concentrations) can be approximated by spiking isotopically labeled (2H or 13C) standards. Specific needs should be discussed in advance.
The service includes the extraction of the metabolites from plasma, serum, or urine using automated liquid handling systems. Different type of samples (biopsies, in vitro tissue culture, feces, saliva, swabs, dried blood spots, ...) require special treatment that should be discussed.
The service includes data processing, QC/QA, putative annotation, expert curation, analysis of batch/drift effects, ev. normalization, and basic differential analysis in case samples groups have been provided (i.e. for unblinded studies).