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Targeted Proteomics course registration is open!
In this course we offer theoretical introductory lectures, comprehensive hands-on training and discussion rounds on each of the typical tasks performed in targeted proteomics workflows. In previous years the focus of the course has been entirely on SRM (selected reaction monitoring). This year the course content is being expanded to include other methods such as PRM (parallel reaction monitoring) and DIA (data independent acquisition), with a particular focus on SWATH MS.
Aebersold lab: Master thesis/semester project in Structural Proteomics
We are looking for motivated semester/master students to join our structural proteomics team at ETH to work at the interface between proteomics and structural biology.
Sauer Group, Metabolism, Systems Biology, Modelling, Bistability
Understanding history-dependence (hysteresis) of growth states in E. coli
Real-time metabolome profiling of the metabolic switch between starvation and growth
The Zamboni and Sauer Lab developed a platform for real-time metabolome profiling by directly injecting living bacteria, yeast or higher cell suspensions into a high-resolution time-of-flight mass spectrometer. We congratulate Hannes and all the coauthors.
Posttranslational regulation of microbial metabolism
In a review published in "Current opinion in Microbiology“, we discuss the division-of-labor between the different regulatory layers in making microbial metabolic decisions, and highlight the current challenges we are facing when elucidating the role of posttranslational regulation.
The outer mucus layer hosts a distinct intestinal microbial niche
In collaboration with the Sauer lab, Hai Li & Julien P. Limenitakis from the Maurice Müller Laboratories (DKF), University of Bern, describe in detail the compositional differences between lumen and outer mucus layer of the intestine in mice and its consequence for the present microbiota.
Cyclic operation of the pentose phosphate, Entner-Doudoroff and glycolytic pathways in Pseudomonas putida
In collaboration with the Sauer lab, Pablo Ivan Nikel from the Centro Nacional de Biotecnologia (CNB-CSIC, Spain), describes a cyclic operation of the pentose phosphate, Entner-Doudoroff and glycolytic pathways in Pseudomonas putida.
Aebersold lab, student (master) project in phosphopeptide enrichment.
We are looking for students who would like to join project for development of the new phosphopeptide enrichent for the analysis of small sample amounts. These projects are the perfect opportunity to get hands-on experience with proteomics methods and mass spectrometry instrumentation. Prior experience with mass spectrometry is not essential, although candidates with basic knowledge of proteomics methods are preferred.