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Patent on Parallel Functionality Testing Synthetic Genome.
Our patent on PARALLEL FUNCTIONAL TESTING OF SYNTHETIC DNA PARTS, PATHWAYS, AND GENOMES was granted by EP and enters nationalization.
Our paper on alpha-synuclein toxicity out in Cell Systems!
Former graduate student Martin Soste studied mechanisms of genes that modulate alpha-Syn toxicity. He used the lab's "sentinel assay" to monitor the activation state of ~200 pathways in yeast and found that blocking the biosynthesis of diacylglycerol, a precursor of lipid droplets, rescued cells from toxicity. Read the paper here: https://doi.org/10.1016/j.cels.2019.07.010