Master/Semestert Project: Metabolome:Proteome Cross-Talk in Basal Autophagy

Autophagy is a major cellular recycling process that is initiated under nutrient deprivation conditions. Critically, the biological process sits at the interface of metabolic, proteomic and organelle-level signaling programs to optimize and preserve cellular homeostasis. This project for a 3 or 6 month master’s student in D-BIOL/D-HEST/D-BSSE dives into the signaling complexity and metabolite:protein crosstalk in basal human autophagy. Specifically, the student will perform experiments in a human tissue culture system and use quantitative metabolomics as a readout. Furthermore the student will develop a state-of-the art top-down proteomics assay to better define early events in autophagy and cross-talk between post-translational modifications on intact proteins.

For more information please contact Dr. Peter Doubleday at