Sauer Group
Systems Biology of Metabolism
The mission of our systems biology research is to identify and quantify the key regulation mechanisms that control cellular metabolism in microbes.
The speciality of our interdisciplinary team of biologists, engineers, and computer scientists are high-throughput experimental technologies for quantitative metabolomics, 13C-based intracellular flux analysis, and dynamic GFP analysis in mini-scale cultivations. Different types of mathematical models are then used to quantitatively relate metabolomics, expression and proteomics data to the functional network output in terms of fluxes. Read more
Contact
Head of Institute for Molecular Systems Biology
Inst. f. Molekulare Systembiologie
Otto-Stern-Weg 3
8093
Zürich
Switzerland
Group news
Sauer Zamboni group achieves LEAF sustainability certification!
The group was one of 19 labs across ETH Zurich to be certified in the LEAF pilot project.
We welcome Jonas Runde as a new PhD student in the lab!
Jonas started his PhD in the group in December, working on protein phosphorylation and post-translational modifications in E. coli. Welcome back Jonas, and viel Erfolg!
The Swiss Chemical Society honors Uwe Sauer with Simon-Widmer Award
The SCS Simon-Widmer Award honors distinguished scientists for their contribution to fundamental and applied analytical science and the education of analytical scientists.
We welcome Vilhelmiina Haavisto as a PhD student in the Sauer lab!
Vilhelmiina starts in January to work on microbial interactions in seawater communities. Good luck Vilhelmiina!
Best poster award to Daniela Ledezma!
Daniela won the best poster award at the "EMBO:Multiomics to Mechanisms symposium." Congratulations Daniela!
Congratulations to Evgeniya Warmer for successful defence of her PhD thesis!
Evgeniya successfully denfended her PhD thesis on phosphoregulation in coordinating E. coli metabolism. Congratulations Evgeniya!
Congratulations to Karin Meier for successful defence of her PhD thesis!
Karin successfully defended her PhD thesis on "Microbial metabolism along the digestive tract and identification of regulatory mechanisms". Congratulations Karin!
Best Talk award to Evgeniya Schastnaya
Congrats Evgeniya for winning the best talk award at the 4th International conference on post-translational modifications in Bacteria (https://www.sysbio.se/ptmbact2020/).
Best poster award to Daniela Ledezma!
Daniela won the best poster award at the EMBO:Multiomics to Mechanisms symposium (https://blogs.embl.org/events/2021/10/14/multiomics-to-mechanisms-best-poster-awards/). Congratulations Daniela!
Best poster prize!
Chris Gruber won the best poster prize at the first in person conference (Quantitative Modeling of Cell Metabolism in Kopenhagen) this year. Congrats Chris!
The Sauer group welcomes Julian Trouillon to his new post-doc position
Julian recently joined the Sauer group and will be developing experimental approaches for systematic determination of metabolite inputs into transcriptional regulatory networks and characterize the regulatory programs dictating metabolic shifts.
Congratulations to Philipp Warmer for successful defence of his PhD thesis!
Philipp succesfully defended his PhD thesis titled: "Towards connecting membrane organisation and cellular homeostasis in prokaryotes by lipidomics". Congratulations to Philipp and wishes of success in future challenges.
A universal trade-off between growth and lag in fluctuating environments
A joint paper from the Basan, Hwa, Paulsson, and Sauer labs reports how rapid microbial growth in one condition compromises the ability to quickly switch to new conditions. This remarkably conserved tradeoff emerges directly from the biochemistry of central metabolism and can mathematically predict broadly disparate growth rates on different substrates.