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Absolute stoichiometry determination of dynamic protein complexes
Mass spectrometry is the widely used accurate quantification of the proteome composition. However very few attempts have been made to use these techniques for the determination of the absolute stoichiometry of protein complexes. The goal of this project is to use Single Reaction Monitoring (SRM)-MS, in combination with AQUA peptides, to define the absolute stoichiometry of dynamically assembling protein complexes that are relevant in the context of inflammation and autoimmune diseases.
New students at Aebersold group!
Luzia Stalder, Chiara Auwerx, Fabian Radler and Varun Sharma have joined the group. Welcome!