Research Groups
Systems Biology of Proteomes
Picotti Group
The group of Prof. Dr. Paola Picotti is interested in how protein conformational changes, such as those associated with protein aggregation or allostery, impact cellular physiology and result in human disease. We develop mass spectrometry-based structural and chemical proteomic methods aimed at monitoring protein conformational changes in the complex cellular milieu. Read more
Gstaiger Group
The systems biology approach of Dr. Matthias Gstaiger and his group is to study biological signaling processes. The goal is a comprehensive understanding of the structure and the dynamics of signaling systems. Read more
Leitner Group
The group of Dr. Alexander Leitner uses different cross-linking methods in combination with mass spectrometric analysis to learn about the structural organization of protein and protein-RNA complexes. Cross-linking can provide important spatial information that can be combined with other experimental and computational methods in integrative structural biology. Read more
Systems Biology of Metabolism
Sauer Group
The group of Prof. Dr. Uwe Sauer combines quantitative experiments with computational analyses to fundamentally understand the coordination of regulation and metabolic networks in bacteria and yeasts. Read more
Zamboni Group
The group of Prof. Dr. Nicola Zamboni develops and applies analytical and computational methods to investigate cellular metabolism, ranging from bacteria to cells and animals. Read more
Systems Biology of Molecular and Celluar Physiology
Snijder Group
The group of Prof. Dr. Berend Snijder combines image-based screening with single-cell analyses, quantitative omics, and computational network analyses, to uncover the organizational principles that govern cellular life in health and disease. Read more
Computational Systems Biology
Beltrao Group
The group of Prof. Dr. Pedro Beltrao studies the cellular consequences of genetic variation with a focus on post-translational regulation.
We aim to develop models of how DNA changes result in differences in biomolecules with an impact on organismal traits. Read more
Systems Biology of Transcriptional Regulation
Trouillon Group
The group of Dr. Julian Trouillon uses and develops sequencing-based methods to study how transcription factors sense molecular signals and interact with DNA to regulate gene transcription and allow bacteria to adapt to changing environments. Read more
Associated Members
Systems proteomics associated members from D-HEST.
Prof. Dr. Bernd Wollscheid