News

Today we say goodbye to Marie-​Therese Mackmull after a successful PostDoc. We will miss you and wish you the best of luck with your future endeavors!

At the D-BIOL Symposium we were able to share our research with the rest of the department. We congratulate Tetiana Serdiuk, Christian Dörig, Cathy Marulli and Franziska Elsässer on their amazing posters!

Monika Pepelnjak successfully defended her PhD thesis today! Congratulations Monika, we are excited to celebrate this milestone with you.

At the 70th ASMS Conference on Mass Spectrometry and Allied Topics, Dina Schuster presented her project "Embracing chaos: studying flexible domains on membrane adenylyl cyclases with structural proteomics". Congratulations on your successful talk!

We welcome back Sabrina Keller for her PhD project in the group of Matthias Gstaiger!

Maria Bikaki gave an intesting talk at the LS2 annual meeting on her project "Structure determination of protein-RNA complexes of SARS-CoV-2 by Cross-Linking of Isotope-labelled RNA and tandem Mass Spectrometry (CLIR-MS)". Congratulations!

Welcome to Izabela Smok who joined the group of Alexander Leitner for her PhD project. We are excited to work with you!

Our PostDoc Tetiana Serdiuk gave a talk at the AD/PD Conference on "Linking alpha-synuclein aggregation and mitochondria". Congratualtions on your successful talk!

We welcome Anna Pagotto as a visiting scientist from the Univeristy of Padova. We are excited to work with you for the next six months!

We are excited to announce that Patrik Stalder successfully defended his PhD thesis today! Congratulations on the great defense!

At the EUbOPEN Annual Meeting 2021, Viviane Reber presented her project. Congratulations on your successful talk!

Jan-Philipp Quast and Dina Schuster published their R package protti that they developed to analyze proteomics data. Congratulations on the amazing work!

We welcome Luca Riermeier as the newest PhD student in the groupf of Alexander Leitner. We are excited to work with you!

At the LS2 Swiss Proteomics Meeting in Montreux, Cathy Marulli and Franziska Elsässer presented their projects, and Franziska even won the Best Presentation Prize. Congratulations on your successful talks!

Jan-Philipp Quast presented the R package protti which he developed together with Dina Schuster at the Basel Computational Biology Conference. We are excited to share our work with the research community!

We are excited to welcome Viviane Reber back as a PhD student in the group of Matthias Gstaiger. We wish you a successful start!

Our paper "Deciphering the signaling network of breast cancer improves drug sensitivity prediction" is out in Cell Systems.

Our paper "Dynamic 3D proteomes reveal protein functional alterations at high resolution in situ" is out in Cell.

We are exctied to welcome back Cathy Marulli for her PhD project where she will work with Alexander Leitner.

Congratulations to Cathy Marulli for being awarded the ETH medal for her outstanding master's thesis "FLiP-MS: Towards Proteome-Wide Identification of Protein-Protein Binding Interfaces and Quantification of Interface Occupancy" supervised by Christian Dörig. 

We welcome our newest PostDoc Maria Bikaki who joined the group of Alexander Leitner. We are excited to work with you!

Congratuations to Jan-Philipp Quast who has received a grant from the Promedica Stiftung to fund his PhD project!

We welcome Viviane Reber to the lab for her master's thesis on Parkinson's disease supervised by Tetiana Serdiuk.

The IMSB labs of Paola Picotti, Uwe Sauer and Mattia Zampieri are part of the just granted National Center of Competence in Research to fight antibiotic-resistant bacteria (NCCR AntiResist). It is a collaboration with colleagues at the Biozentrum and University Hospital Basel and the ETH Department of Biosystems in Basel. The aim is to find new antibiotics and develop alternative strategies to combat antibiotic-resistant bacteria by linking basic research directly with clinical research.

Former graduate student Martin Soste studied mechanisms of genes that modulate alpha-Syn toxicity. He used the lab's "sentinel assay" to monitor the activation state of ~200 pathways in yeast and found that blocking the biosynthesis of diacylglycerol, a precursor of lipid droplets, rescued cells from toxicity. Read the paper here: https://doi.org/10.1016/j.cels.2019.07.010

Former lab member Juan Gerez (now in the Riek lab) found a new ubiquitin ligase complex that targets internalized alpha-synuclein fibrils for degradation. https://stm.sciencemag.org/content/11/495/eaau6722.full  

Paola has been awarded the EMBO gold medal. It is awarded every year to young scientists who have made outstanding contributions to life sciences in Europe. Congratulations to Paola!

Natalie de Souza joined our group in April 2019 as a Scientific Officer and Lecturer.

Jan-Philipp Quast will do his PhD in our lab.

Franziska Elsässer joined our lab as a PhD student in April 2019.  

We welcome Aleš Holfeld! He will be performing his PhD project in our group.  Good luck!  

We welcome back Alex in our lab. She has been a Masters' student and now she will stay with as a research intern. Good luck, Alex!

Together with the rest of IMSB we moved our lab to a new building. For us it meant a physical move of one floor down and a few meters back, but it gave use the opportunity to put together a nice, big, open-space lab and equip it with all new instruments and items. You can find us now in HPM2, D24. Our mass specs joined the mass specs of the other IMSB groups in a massive underground lab. Watch some pictures of the progress

Big congratulation to Ilaria for winning the Early Career Researcher competion 'highlight of the year'!   

A big welcome to Christian Dörig who is starting in our group as a PhD student. All the best for your project!

We welcome Marie-Therese Mackmull to our lab as a post-doctoral fellow!

Big congratulations to Paola and Ilaria as they both won a prize at this year's EuPA.

Congrats to Ilaria and Paola as their collaboration with the Sauer group and groups in Basel and Paris led to a paper in Science Translational Medicine: High-throughput metabolomic analysis predicts mode of action of uncharacterized antimicrobial compounds.

We thank Drs. Kuroda and Papp for recommending our article "A Map of Protein-Metabolite Interactions Reveals Principles of Chemical Communication" in Faculty of 1000.

Congratulations to Ilaria, Valentina, Paola and members of the Sauer lab as their paper 'A Map of Protein-Metabolite Interactions Reveals Principles of Chemical Communication' was accepted by Cell and is now online. The paper presents a chemoproteomic workflow for the systematic identification of metabolite-protein interactions directly in their native environment. 

We just received the exciting news that Paola will get the 2018 Friedrich-Miescher-Award from the Molecular and Cellular Biosciences section of Life Sciences Switzerland. Congratulations to her!

Congrats to almost all of us: the protocol paper in which we practically describe the method of coupling limited proteolysis to mass spectrometry is now out in Nature Protocols! This will be an important starting point for external labs to try out this exciting and powerful method.

A warm welcome to Patrick Stalder and Monika Pepelnjak who have started their PhD-project and fast track Master/PhD-project, respectively, in our lab.

Congratulations to Yuehan, Valentina and Paola as their review on quantitative proteomics of model organisms is now published in Current Opinion in Systems Biology. 

Although they did not yet move their lab physically, the Picotti group has just changed affiliation by joining the Institute of Molecular Systems Biology of ETH Zurich, where Paola obtained a tenured position. 

Congratulations to Yuehan and Paola as there collaborative effort with members of the Matthias Peter lab was published in Nature Cell Biology!

Our recent paper "Cell-wide analysis of protein thermal unfolding reveals determinants of thermostability" (Leuenberger et al. Science 2017) is discussed in the Quanta Magazine.

Our recent Science paper was recommended by faculty members at Faculty of 1000.

Our recent paper "Cell-wide analysis of protein thermal unfolding reveals determinants of thermostability" (Leuenberger et al. Science 2017) is highlighted in BioTechniques. 

The Neue Zürcher Zeitung (the Swiss newspaper of record) has published an article about our recent paper in Science. 

Our paper on the study of the determinants of proteome thermostability that was just published in Science has been highlighted in the ETH News.

Our paper entitled "Cell-wide analysis of protein thermal unfolding reveals determinants of thermostability" has just been published in Science.

Welcome (back) to Valentina Cappelletti and Thomas Hauser. They will start their post-doc projects in our lab from today onwards. Good luck!

We welcome Lili Malinovska who will join our lab as a Post-doc. All the best for your project!

Martin was awarded the Silver Medal of ETH for “Outstanding Doctoral Theses”. That means that Martin’s thesis was among the top 5% PhD theses awarded by ETH each year, based on a jury of international reviewers. Btw, there are no gold or bronze medals.

We are proud to announce that Paola has won another prize: the Swiss Group for Mass Spectrometry (SGMS) award.

Nature Biotechnology asked a selection of researchers about the most exciting frontier in their field and the most needed technologies for advancing knowledge and applications. Also Paola was asked for her opinion.

We're to proud to have learned that Paola has won the 2016 Robert J. Cotter new investigator award for her significant achievements in proteomics.

Paola, Andre and Juan contributed to two projects of which the results were recently published in Journal of Biological Chemistry and PLoS Genetics.

Congrats to Valentina Cappelletti who received a EMBO short term fellowship to perform part of her PhD project in our lab!

As part of the Springer Protocols Methods in Molecular Biology book entitled Proteomics in Systems Biology, Yuehan and Paola wrote a practical guide about Selected Reaction Monitoring to Measure Proteins of Interest in Complex Samples.

Paola Picotti was selected as EMBO Young Investigator. Congratulations!

Welcome to Valentina Cappelletti who will visit our lab for several months.

Congrats to Martin who succesfully defended his PhD.

The review, Proteomics beyond large-scale protein expression analysis, that Paul, Abdullah and Paola wrote for Current Opinion in Biotechnology is now online.

We started our new year with two new group members: Natalia Prymaczok and Marco Tognetti. 

Congratulations to Ilaria who won a EMBO long-term fellowship!

Our limited proteolysis SRM paper was highlighted in Nature Methods.

Paola Picotti made it into The Analytical Scientist's Top 40 under 40!

Paola contributed to the review.

Paola was interviewed by Nature Methods on the occasion of the publication of the sentinel paper and appears in The Author File.

Our paper "Global analysis of protein structural changes in complex proteomes" alias the LiP paper is online on the Nature Biotechnology website.

The paper "A sentinel protein assay for simultaneously quantifying cellular processes" is now available for download on the Nature Methods website.

Yuehan and Paola contributed to the paper "Stepwise priming by acidic pH and high K+ is required for efficient uncoating of influenza A virus cores after penetration" that was just accepted in Journal of Virology. Congratulations!

Martin and Paola contributed to the paper "Calcineurin determines toxic versus beneficial responses to α-synuclein" that is now published in PNAS. Congrats!

A warm welcome to Ilaria Piazza who joined our team as a post-doc.

Congratulations to Yuehan, Paola et al. as their LiP-SRM paper was accepted in Nature Biotechnology

A warm welcome to Simone Schopper who started a post-doc project in our lab.

Congrats to Juan and Paola: the paper Accumulation of oligomer-prone α-synuclein exacerbates synaptic and neuronal degeneration in vivo they contributed to was published in Brain!

A big welcome to our 'new' PhD student Pascal Leuenberger and semester students Marc van Oostrum and Carmen Schwarz!

We welcome our Erasmus student Filip.

Martin Soste and Paola Picotti wrote a short review as part of a 'Highlights of Analytical Sciences in Switzerland' in CHIMIA about a complete mass-spectrometric map of a eukaryotic proteome.

We are welcoming our semester students Gea and Marta.

Wishing Andre, Martin and Yuehan good luck at HUPO 2013 and fun at the other side of the world!

Many congratulations to Paola. She got awarded an ERC starting grant!

Congratulations to Francesco, Martin, Yuehan and Paola; their paper "Reproducibility of combinatorial peptide ligand libraries for proteome capture evaluated by selected reaction monitoring" was accepted for publication in Journal of Proteomics!